Adsorption of Diazepam to Plastic Tubing

Publisher Website
Google Scholar
Abstract
To the Editor: Diazepam has become one of the mainstays of therapy for convulsions, anxiety and preoperative and postoperative anesthesia.1 We have recently observed extensive adsorption of diazepam to plastic tubing during continuous infusion. Plasma concentrations of diazepam after such infusions are therefore much lower than predicted.A multiple-infusion regimen, designed to rapidly attain and maintain plasma concentrations of diazepam at 400 to 500 ng per milliliter, was tested in a 15-month-old girl (10.5 kg) with recurrent seizures who had become unresponsive to her usual anticonvulsant regimen. Diazepam (Roche Laboratories, Nutley, New Jersey) was diluted in glass containers of sterile . . .

This publication has 2 references indexed in Scilit: