The pathogenesis of endemic (egyptian) splenomegaly

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Abstract
1. 1. The pathological findings in 1,400 cases of endemic Egyptian splenomegaly are described. 2. 2. The cause of the disease is infection with ova of one or both of the parasites, Schistosoma haematobium and S. mansoni . 3. 3. The splenic enlargement is due to response of the reticulo-endothelial tissue of the spleen to deposition of ova in it. As a result there is a cellular response which quickly ends in digestion and removal of the solid remains (parts of the egg-shell) of the ova. With frequent repetition of the process, under the condition of perpetual re-infection in which the patients live, there is produced ultimately a condition of permanent hyperplasia and fibrosis. 4. 4. The splenic enlargement is not dependent on either intestinal or hepatic lesions.
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