Pilot trial of immunoglobulin versus plasma exchange in patients with Guillain-Barre syndrome
- 1 January 1996
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Neurology
- Vol. 46 (1) , 100-103
- https://doi.org/10.1212/wnl.46.1.100
Abstract
Article abstract-We compared intravenous immunoglobulin (IVIG) and plasma exchange (PLEX) in the treatment of 50 patients with Guillain-Barre syndrome (GBS). Standard outcome measures did not differ for the two groups. Sixty-one percent of the PLEX-treated group and 69% of the IVIG-treated group improved by one disability grade at 1 month. The complication rate was higher in the PLEX-treated group. We conclude that the efficacy of IVIG in the treatment of GBS is comparable with that of PLEX and that it can be used safely, although we had a small number of patients. We did not observe a higher relapse rate with IVIG. The usefulness of combination therapy is unknown at this time. NEUROLOGY 1996;46: 100-103Keywords
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