Amoxicillin Pharmacokinetics in Pregnant Women: Modeling and Simulations of Dosage Strategies
- 28 February 2007
- journal article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 81 (4) , 547-556
- https://doi.org/10.1038/sj.clpt.6100126
Abstract
Amoxicillin is recommended for anthrax prevention in pregnancy. The objective of this study was to evaluate the pharmacokinetics of amoxicillin during pregnancy and postpartum (PP). Sixteen women received amoxicillin during gestation (18–22 weeks (T2) and 30–34 weeks (T3)) as well as 3 months postpartum (PP) to evaluate single‐dose pharmacokinetics. Amoxicillin compartmental pharmacokinetic parameters were used to simulate amoxicillin concentration–time profiles following different dosage strategies. Amoxicillin CLrenal (T2: 24.8±6.7 l/h, PPsecretion (T2: 280±105 ml/min, PPrenal and renal CLsecretion reflect increases in filtration and secretory transport or diminished reabsorption in the kidneys. Amoxicillin may not be an appropriate antibiotic for post‐anthrax exposure prophylaxis. Clinical Pharmacology & Therapeutics (2007) 81, 547–556. doi:10.1038/sj.clpt.6100126; published online 28 February 2007.Keywords
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