Application of P-Stereogenic Aminophosphine Phosphinite Ligands in Asymmetric Hydroformylation
- 17 April 2000
- journal article
- Published by Wiley in Chemistry – A European Journal
- Vol. 6 (8) , 1496-1504
- https://doi.org/10.1002/(sici)1521-3765(20000417)6:8<1496::aid-chem1496>3.0.co;2-8
Abstract
New chiral aminophosphine phosphinite ligands with a stereogenic center at the aminophosphine phosphorus atom were prepared based on (R,S)‐ephedrine as the chiral auxiliary and backbone. Substituents at the chiral aminophosphine as well as at the phosphinite phosphorus atom were varied. These new ligands were applied to the rhodium‐catalyzed asymmetric hydroformylation of vinyl arenes. The enantiomeric excess reached up to 77 %. 1H and 31P NMR studies of the Rh complexes under syngas pressure reveal that [HRh(CO)2(P∧P)] complexes with the NP* moiety in an axial position are responsible for enantioselectivity.Keywords
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