Stimulation of phosphoinositide hydrolysis via class I antigen‐specific recognition in murine cardiac tissue
- 5 June 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 249 (2) , 302-306
- https://doi.org/10.1016/0014-5793(89)80646-5
Abstract
Induction of polyphosphoinositide hydrolysis in cardiac tissue by specific recognition of class I histocompatibility antigens was assayed. C3H (H‐2k) mice auricles were labelled with myo‐3H]inositol precursor and inositol phosphate production in the presence or absence of anti‐class I k products was measured. Anti‐class I, but not anti‐class II products specifically increased phosphoinositide turnover. This increment was partially blocked by muscarinic cholinergic and α‐adrenergic blockers and even more so by the phospholipase C inhibitor NCDC. Alloantibodies specifically directed against class I antigens could then exert stimulation of phospholipase C‐mediated phosphoinositide hydrolysis through the interaction with muscarinic cholinergic and/or α‐adrenergic receptors. The induction of intracellular second messengers by class I antigens and hormone‐receptor interactions is discussed.Keywords
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