[Synthesis and physico-chemical properties of the antihypertensive agent urapidil (author's transl)].

  • 1 January 1977
    • journal article
    • abstracts
    • Vol. 27  (10) , 1895-7
Abstract
6-(3-[4-(o-Methoxyphenyl)-1-piperazinyl]-propylamino)-1,3-dimethyluracil (Urapidil, Ebrantil) is a new antihypertensive agent whose synthesis and physico-chemical properties are described. The size of the permeation constant KD of the passive transport through collodion-lecithin membranes and the value of the partition coefficient P in the neutral area indicate a good absorption and uniform distribution of the substance in the organism.

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