Enantioselective separations by capillary GC on derivatized cyclodextrins. Part 1: Separation of some racemic 2,2‐dialkyl‐4‐alkoxycarbonyl‐1,3‐dioxolane derivatives on permethylated α‐, β‐ and γ‐cyclodextrins

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Abstract
The enantioseparation of some 2,2‐dialkyl‐4‐alkoxycarbonyl‐1,3‐dioxolane derivatives, which are important intermediates in the total synthesis of a number of biologically active compounds, was studied by means of capillary gas chromatography (CGC). The chromatographic results, obtained on columns coated with permethylated α‐, β‐ and γ‐cyclodextrin respectively, are reported. Out of sixteen compounds, thirteen could be separated with a resolution superior to 1,2. One racemate could not be separated on any of the columns. Considerations concerning the separation mechanism are proposed.