Nonchromosomal Heredity

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Abstract
SOME applications of the science of genetics to the practice of medicine were clearly stated in 1908 by the English physician, Garrod,1 in his now famous book, Inborn Errors of Metabolism. Garrod had been impressed by the case histories of patients with alcaptonuria, cystinuria and certain other congenital diseases. In his book he proposed that these diseases were each the result of a gene mutation leading to an altered metabolic pathway. He anticipated in an impressive manner the subsequent evidence and thinking that led Beadle and Tatum to propose in 1941 the "one gene one enzyme" hypothesis: that single . . .