Editorial
- 1 February 1962
- journal article
- editorial
- Published by Wolters Kluwer Health in Circulation
- Vol. 25 (2) , 273-276
- https://doi.org/10.1161/01.cir.25.2.273
Abstract
This article deals with the mechanism of homograft rejection of the transplanted, canine heart. The technique was used in the operation of Mann. Two dissimilar pathological processes were observed. One consisted of diffuse pancarditis similar to the proliferative stage of rheumatic fever. Aschoff body like changes were seen. The 2d lesion involved necrosis of the transplant. Metabolic studies on the transplanted dog heart reveal that the hydrogen transfer system is intact but that there exist definite metabolic blocks due to increased permeability of the cell. This results in loss of enzymes and coenzymes from the myocardium. Survival was up to 47 days.Keywords
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