APPEARANCE OF INTESTINAL TYPE OF TUMOR-CELLS IN HEPATOMA TISSUE INDUCED BY "3'-METHYL-4-DIMETHYLAMINOAZOBENZENE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (9) , 2753-2758
Abstract
Carcinoma tissues induced in rats by 3''-methyl-4-dimethylaminoazobenzene were investigated morphologically and biochemically. The most prominent histological pattern was an undifferentiated carcinomatous one. While this type of carcinoma, histologically, appeared to be due to a uniform population of cells, EM examination revealed that the carcinoma tissue was composed of many types of cells including cells that contained the brush border or mucous droplets seen in goblet cells. Tumor cells that contain serotonin-like granules were noticed. An electrophoretogram of alkaline phosphatase in the tissue extract of this type of carcinoma revealed the presence of its intestinal isozyme. These findings show that carcinoma induced by 3''-methyl-4-dimethylaminoazobenzene includes, in addition to cells differentiated toward hepatocytes or cholangiolar cells, those differentiated toward intestinal epithelial cells.