Disposition and Metabolic Profiles of [ 14 C]Viramidine and [ 14 C]Ribavirin in Rat and Monkey Red Blood Cells and Liver
Open Access
- 1 May 2004
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (5) , 1872-1875
- https://doi.org/10.1128/aac.48.5.1872-1875.2004
Abstract
The disposition and metabolic profiles of [ 14 C]viramidine and [ 14 C]ribavirin were compared in rat and monkey red blood cells and liver. Our data reveal that the total ribavirin-related components (ribavirin plus its mono-, di-, and triphosphate metabolites) may account for most of the drug in monkey liver following prolonged oral administration of viramidine.Keywords
This publication has 20 references indexed in Scilit:
- Pharmacokinetics and Metabolism of [ 14 C]Viramidine in Rats and Cynomolgus MonkeysAntimicrobial Agents and Chemotherapy, 2003
- Pharmacokinetics and Metabolism of [14C]Ribavirin in Rats and Cynomolgus MonkeysAntimicrobial Agents and Chemotherapy, 2003
- Activation and Deactivation of a Broad-Spectrum Antiviral Drug by a Single Enzyme: Adenosine Deaminase Catalyzes Two Consecutive Deamination ReactionsAntimicrobial Agents and Chemotherapy, 2003
- A Randomized, Double–Blind Trial Comparing Pegylated Interferon Alfa–2B to Interferon Alfa–2B As Initial Treatment for Chronic Hepatitis CHepatology, 2001
- Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis CNew England Journal of Medicine, 1998
- Ribavirin uptake by human erythrocytes and the involvement of nitrobenzylthioinosine‐sensitive (es)‐nucleoside transportersBritish Journal of Pharmacology, 1998
- Metabolism of ribavirin in respiratory syncytial virus-infected and uninfected cellsAntimicrobial Agents and Chemotherapy, 1986
- Effects of ribavirin on red blood cellsToxicology and Applied Pharmacology, 1984
- THE RELATIONSHIP BETWEEN THE METABOLISM OF RIBAVIRIN AND ITS PROPOSED MECHANISM OF ACTIONAnnals of the New York Academy of Sciences, 1977
- Broad-Spectrum Antiviral Activity of Virazole: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamideScience, 1972