Rapid Recovery of Bone Mass in Hypercalciuric, Osteoporotic Men Treated with Hydrochlorothiazide

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Abstract
Chronic hypercalciuria can contribute to osteoporosis, particularly in men. To ascertain the effects of resolution of hypercalciuria on bone mineral density. Case series. Referral service for metabolic bone disease in a tertiary-care teaching hospital. Five male patients (42 to 66 years of age) with hypercalciuria and osteoporosis. Hydrochlorothiazide, 25 mg twice daily, for a mean (± SD) of 7.8 ± 3.6 months. Fasting urinary calcium:creatinine ratio, serum calciotropic hormone levels, and bone mineral density before and after hydrochlorothiazide administration. Hydrochlorothiazide resolved hypercalciuria and increased bone mineral density at a rate of 8% and 3% per year at the spine and hip, respectively. Hydrochlorothiazide treatment in hypercalciuric and osteoporotic men was associated with a rapid rebound increase in bone mineral density.

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