ERYTHROCYTE CREATINE LEVELS IN ANEMIA

  • 1 January 1982
    • journal article
    • research article
    • Vol. 12  (6) , 439-446
Abstract
The automated diacetyl-l-napthol procedure was a simple and relatively quick method for the determination of erythrocyte creatine (EC), exhibiting both better precision and greater sensitivity than reticulocyte counting. A reference range of 1.8-5.0 mg/dl (mean, 3.0 .+-. 0.9) was established by measuring EC levels in 81 normal adults aged 20-47 yr. Normal creatine values displayed a slight sex dependency, with females exhibiting somewhat higher levels than males. In evaluating the relative usefulness of EC vs. reticulocyte counting in the assessment of anemia, both parameters were measured and compared in 41 patients with various hemolytic and nonhemolytic anemias. A direct relationship was noted between the 2 parameters (P < 0.0001); however, the actual data correlation was only fair (r = 0.49). In a serial study of an Fe-deficiency anemic patient responding to Fe administration, EC levels rose more slowly than the reticulocyte count and remained elevated after the reticulocyte count had returned to normal.

This publication has 7 references indexed in Scilit: