In vivo suppression of T‐dependent antibody responses by treatment with a monoclonal anti‐L3T4 antibody
- 1 January 1985
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 15 (6) , 638-640
- https://doi.org/10.1002/eji.1830150620
Abstract
Minute amounts of the anti-L3T4 antibody designated GK1.5 were found to deeply suppress in vivo antibody responses to T-dependent antigens. Primary responses to sheep erythrocytes were completely inhibited even when GK1.5 was administered up to 6 days before or 4 days after the antigen. Secondary responses to potent immunogens like sheep erythrocytes or keyhole limpet hemocyanin were also completely abolished by a single injection of GK1.5 just before the boost. This treatment had no effect on T-independent reactions such a s the polyclonal activation of B lymphocytes with lipopolysaccharide or the anti-2, 4,6- trinitrophenyl (TNP) response elicited by injection of TNP-Ficoll.This publication has 15 references indexed in Scilit:
- Therapy with monoclonal antibodies by elimination of T-cell subsets in vivoNature, 1984
- Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5.The Journal of Experimental Medicine, 1983
- Rheumatoid factors and secondary immune responses in the mouse II. Incidence, kinetics and induction mechanismsEuropean Journal of Immunology, 1983
- Epitope-specific regulation. I. Carrier-specific induction of suppression for IgG anti-hapten antibody responsesThe Journal of Experimental Medicine, 1982
- TREATMENT OF ACUTE RENAL ALLOGRAFT REJECTION WITH OKT3 MONOCLONAL ANTIBODYTransplantation, 1981
- Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.Proceedings of the National Academy of Sciences, 1981
- IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.The Journal of Immunology, 1980
- T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views.The Journal of Experimental Medicine, 1980
- Mouse alloantibodies capable of blocking cytotoxic T-cell function. I. Relationship between the antigen reactive with blocking antibodies and the Lyt-2 locus.The Journal of Experimental Medicine, 1979
- Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antiseraProceedings of the National Academy of Sciences, 1979