SEQUENTIAL STUDIES ON COMPONENTS OF THE HAEMOSTATIC MECHANISM IN PREGNANCY WITH PARTICULAR REFERENCE TO THE DEVELOPMENT OF PRE‐ECLAMPSIA

Publisher Website
Google Scholar
Abstract
Components of the haemostatic mechanism were studied at intervals in 60 primigravidae over the course of pregnancy and the puerperium; 12 of these developed pre-eclampsia. During pregnancy there was a fall in fibrinolytic activity and fibrinolytic capacity and a rise in fibrinogen, FR-antigen, α1-antitrypsin and α2-macroglobulin. The women who subsequently developed pre-eclampsia could not be identified on the basis of these measurements. Following delivery there was a more rapid return of fibrinolytic activity and capacity towards normal in the women who had not had pre-eclampsia. The urinary FR-antigen level was higher in the women with pre-eclampsia.