A Comparison of Topical Betoptic and Timoptic on Corneal Re-Epithelialization in Rabbits

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Abstract
Rabbit corneal epithelial wound healing was studied clinically and with scanning electron microscopy after topical application of Timoptic and Betoptic. On the first and second day after debridement, the healing rates were similar. By the third and fourth day, however, the healing rate of the Timoptic-treated group was significantly slower than the Betoptic-treated group (p < 0.01). By the 20th day the Timoptic group showed extensive epithelial plasma membrane defects, while the Betoptic group did not. Betoptic therefore appears to be less toxic than Timoptic to healing corneal epithelium.

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