Synthesis of Prostanoids. I. A Highly Convergent Approach to 13-oxi-Prostanoids
- 1 January 1976
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 6 (1) , 39-45
- https://doi.org/10.1080/00397917608062131
Abstract
At present, synthetic entry to the biologically active 13-oxi-prostanoids involves allylic rearrangement2 or the Wharton inversion sequence3 from their 15-oxi-derivatives. We wish to present now our results on a totally synthetic, highly convergent approach to these compounds (e.g. 1a and 1b) which uses the conjugate addition-enolate trapping sequence4. Recently, this methodology has been used for construction of a model of the prostanoid skeleton5, as well as in C-20 prostanoids6.Keywords
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