Stimulation of Indole Alkaloid Production in Cell Suspension Cultures ofCatharanthus roseusby Abscisic Acid
- 1 October 1987
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 53 (05) , 470-474
- https://doi.org/10.1055/s-2006-962775
Abstract
When added to suspension cultures of Catharanthus roseus, abscisic acid (ABA) stimulated intracellular accumulation of the indole alkaloids catharanthine and ajmalicine in both flask and 30 litre fermenter-scale systems. The response varied, and depended upon the cell line, the concentration and source of the ABA, and the growth phase at which the cells were treated. Precise timing of ABA addition to cells in a 301 fermenter resulted in a catharanthine yield of 85.25 mg/l after 10 days of cultivation. We propose that ABA may be useful for increasing the yield and reducing the production time for commercially useful secondary plant metabolites.This publication has 1 reference indexed in Scilit:
- Stress and Secondary Metabolism in Cultured Plant CellsPublished by Springer Nature ,1984