Influence of Hypophysis and of Adrenal Cortex upon Tissue Mast Cell of the Hamster.

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Abstract
Mast cell counts were made on skin, mesentery, and cheek pouch of Syrian hamsters subjected to adrenalectomy, hypophysectomy, and treatment with ACTH or cortisone. None of the treatments influenced the total number of mast cells. Neither adrenalectomy nor hypophysectomy affected the number of abnormal (vacuola-tion and conglomeration of cytoplasmic granules) mast cells. Both cortisone and ACTH administration were followed by increases in the number of abnormal mast cells, these being especially great in the mensentery. ACTH was without influence when given to adrenalectomized animals.