Abstract
This review discusses the increased permeability and enhanced uptake transport of monovalent and divalent cations following mitogen-induced lymphocyte roliferation. The observed Ca2+ uptake is discussed in terms of gated Ca2+ channels. The importance of divalent cations, particularly Ca2+, is discussed in terms of triggering of cytotoxic effector cell responses for three model systems (antibody dependent cytotoxicity, mitogeninduced cytotoxicity and cell mediated cytotoxicity); (85).

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