PMR Assay of ?-Lactm Antibiotics 1: Assay Of Cephalosporins

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Abstract
A PMR method for quantitative determination of cephalosporins namely cephalotin, cephaloridine, cephradine, cefoxitin and cefotaxime in bulk drugs and pharmaceutical formulation are presented. The determination is based on the integration of the 6-H and/or 7-H of the β-lactam ring system relative to that of the nine protons of t-butanol. The method is rapid, accurate and precise, with an average standard deviations of ± 1.51 in standard mixtures and ± 1.15 in pharmaceutical formulation. The procedure furnishes a specific means of identification of each individual cephalosporin as well as detection of the commonly encountered impurites.