Trypsin-Catalyzed Peptide Synthesis with Various p-Guanidinophenyl Esters as Acyl Donors.

Publisher Website
Google Scholar
Abstract
Trypsin-catalyzed peptide synthesis has been studied by using p-guanidinophenyl esters of N alpha-(tert-butyloxycarbonyl)amino acid and peptide as acyl donor components. The reaction conditions were optimized for organic solvents, pH, and concentration of acceptor. The method was especially useful for the preparation of various peptides containing D-amino acids. The enzymatic hydrolysis of the resulting products was negligible.

This publication has 0 references indexed in Scilit: