Effects of acute doses of zimelidine on REM sleep in rats
- 1 June 1983
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 80 (3) , 214-216
- https://doi.org/10.1007/bf00436155
Abstract
Sleep EEG (7 h) were obtained from 11 rats given 5, 10, and 20 mg/kg zimelidine, and a control dose of saline. Zimelidine significantly suppressed REM sleep, lengthened REM latency, and reduced total sleep time (TST) in a dose-dependent manner. Sleep latency was not affected except at the highest dose of zimelidine. Slow-wave sleep (SWS) was not affected at any dose. The results are discussed in terms of their implication for the use of zimelidine in the clinical treatment of depression.Keywords
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