Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood–CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis
Top Cited Papers
- 1 April 2000
- journal article
- Published by Wiley in The FASEB Journal
- Vol. 14 (5) , 691-698
- https://doi.org/10.1096/fasebj.14.5.691
Abstract
Peroxynitrite (ONOO−), a toxic product of the free radicals nitric oxide and superoxide, has been implicated in the pathogenesis of CNS inflammatory diseases, including multiple sclerosis and its a...Keywords
Funding Information
- Kosciuszko Foundation
This publication has 43 references indexed in Scilit:
- Nitric Oxide Synthase in Reactive Astrocytes Adjacent to β-Amyloid PlaquesExperimental Neurology, 1997
- Nitric oxide inhibits the secretion of T‐helper 1‐ and T‐helper 2‐associated cytokines in activated human T cells‘paImmunology, 1997
- DNA strand breakage and activation of poly-ADP ribosyltransferase: A cytotoxic pathway triggered by peroxynitriteFree Radical Biology & Medicine, 1996
- Protection Against Peroxynitrite-Dependent Tyrosine Nitration and α1-Antiproteinase Inactivation by Ascorbic Acid. A Comparison with other Biological AntioxidantsFree Radical Research, 1996
- Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brainsAnnals of Neurology, 1994
- Molecular evolution of the urate oxidase-encoding gene in hominoid primates: nonsense mutationsGene, 1991
- A Requirement for the Intercellular Messenger Nitric Oxide in Long-Term PotentiationScience, 1991
- Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.Proceedings of the National Academy of Sciences, 1981
- Similar Functions of Uric Acid and Ascorbate in Man ?Nature, 1970
- THE BIOLOGICAL SIGNIFICANCE OF URIC ACID AND GUANINE EXCRETIONBiological Reviews, 1959