Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9
- 15 July 2006
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 16 (14) , 3751-3754
- https://doi.org/10.1016/j.bmcl.2006.04.048
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Regulation of transcription elongation by phosphorylationBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002
- Pharmacological inhibitors of cyclin-dependent kinasesTrends in Pharmacological Sciences, 2002
- Regulation of RNA polymerase II activity by CTD phosphorylation and cell cycle controlJournal of Cellular Physiology, 2002
- Structure-Based Generation of a New Class of Potent Cdk4 Inhibitors: Newde NovoDesign Strategy and Library DesignJournal of Medicinal Chemistry, 2001
- A decade of CDK5Nature Reviews Molecular Cell Biology, 2001
- CDK inhibitors: positive and negative regulators of G1-phase progressionGenes & Development, 1999
- The regulation of E2F by pRB-family proteinsGenes & Development, 1998
- Cancer Cell CyclesScience, 1996
- Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human CancerAdvances in Cancer Research, 1996
- Cyclins and Cyclin-Dependent Kinases: Theme and VariationsAdvances in Cancer Research, 1995