Lisinopril dose‐response relationship in essential hypertension.

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Abstract
1. This was a multicentre, double‐blind, parallel study in 216 patients with mild to moderate (supine diastolic blood pressure = 95‐115 mm Hg) essential hypertension. 2. After a 4‐week placebo washout, patients were randomized to placebo or lisinopril 1.25, 5.20 or 80 mg once daily for 6 consecutive weeks. Supine and erect blood pressure was measured 24 h postdose at the end of weeks ‐2, 0, 2, 4, and 6. 3. There was a linear dose‐response relationship for both supine and erect blood pressure. Diastolic blood pressure reductions in the lisinopril 20 and 80 mg day‐1 groups were significantly greater than in the placebo or lisinopril 1.25 and 5 mg day‐1 groups. 4. Lisinopril, at doses up to 80 mg day‐1, was well tolerated.