Alternative splicing of the human Shaker K+ channel β1 gene and functional expression of the β2 gene product
- 14 August 1995
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 370 (1-2) , 32-36
- https://doi.org/10.1016/0014-5793(95)00785-8
Abstract
Mammalian voltage-activated Shaker K+ channels associate with at least three cytoplasmic proteins: Kvβ1, Kvβ2 and Kvβ3. These β subnunits contain variable N-termini, which can modulate the inactivation of Shaker α subunits, but are homologous throughout an aldo-keto reductase core. Human and ferret β3 proteins are identical with rat β1 throughout the core while β2 proteins are not; β2 also contains a shorter N-terminus and has no reported physiological role. We report that human β1 and β3 are derived from the same gene and that β2 modulates the inactivation properties of Kv1.4 α subunitsKeywords
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