Glomerular Filtration Rate and Renal Plasma Flow in Patients with Essential Hypertension before and after Treatment with Alprenolol

Publisher Website
Google Scholar
Abstract
In 25 patients with essential hypertension, the renal plasma flow (RPF), glomerular filtration rate (GFR) and BP (blood pressure) were measured before and after 1 mo. treatment with alprenolol. The patients were divided into 2 groups according to age. Group 1 consisted of 10 patients with mild hypertension under 35 yr of age, group 2 of 15 patients over the age of 35 with moderate hypertension. A markedly greater lowering of BP was measured in group 1 than in group 2. There were no changes in RPF or GFR after alprenolol treatment and no differences in these parameters were observed between the 2 groups either before or after treatment. Group 1 displayed significantly lower renal vascular resistance (RVR) than group 2 both before and after treatment, and alprenolol treatment resulted in a slight reduction of RVR in group 1, but not in group 2. The difference between the 2 groups with respect to the antihypertensive effect of alprenolol and the RVR may possibly be due to the fact that the patients in group 2 had more pronounced, structural vascular alterations than those in group 1.