CORTEX ARCHITECTONICS IN MICE SELECTED FOR THE HIGH AND LOW BRAIN-WEIGHT

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 33  (3) , 576-582
Abstract
The cortex cytoarchitectonics was studied in mice, genetically selected for high (H-line) and low (L-line) brain weight and behavioral differences. Microscopic brain sections were analyzed to estimate the areas of the neocortex, archicortex and paleocortex and to investigate quantitatively the microstructure in different zones of the neocortex. In the H-line, absolute value of total cortical area is, on the average, 18% higher than that in the L-line.sbd.mainly due to the larger area of neocortex, while the mean values of neuron volume fraction and profile field reveal no significant difference between the H- and L-line. The total number of neurons in the neocortex of mice from H-line should be greater than that in the L-line. Within the framework of the same cerebral organization in general, the obtained data were indicative of a somewhat higher spatial differentiation of the neocortex in mice from the H-line.