Functional Affinity of Antibody to the Haemophilus influenzae Type b Polysaccharide

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Abstract
The functional affinity, or avidity, of antibody to the capsular polysaccharide of Haemophilus influenzae (Hib-PS) was measured in serum samples from 12 adult male subjects before and after immunization with Hib-PS vaccine. Mean avidity increased from 0.74 nM−1 to 1.5 nM−1 after immunization (P < .05, paired Student's t test). The Bureau of Biologics reference antiserum had an avidity constant of 12nM−1, which was the highest of all 25 serum samples studied.