Identification of Patients With Head and Neck Cancer Using Serum Protein Profiles

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Abstract
HEAD AND NECK SQUAMOUS cell cancer (HNSCC) can be a devastating disease, comprising over 5% of all cancers in the United States and an even larger proportion of cancers worldwide.1 Tobacco and alcohol consumption are well-established risk factors for HNSCC. Despite many advances in the treatment of HNSCC over the past 30 years, little progress has been made in improving survival rates. These tumors are often discovered in advanced stages with treatment frequently leaving patients disfigured and with debilitating adverse effects of radiation and chemotherapy, compromised speech and swallowing, and significantly diminished quality of life.