Euthyroid, Familial Hyperthyroxinemia

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Abstract
To the Editor: We have studied the occurrence of euthyroid hyperthyroxinemia in eight of 13 family members representing four generations. All hyperthyroxinemic subjects had an elevated serum concentration of total thyroxine (T4) that could not be explained by abnormalities in binding proteins or in T4 transport. Each of these subjects had a normal serum content of triiodothyronine (T3). The peripheral deiodination of T3 and of reverse T3 also appeared to be at least qualitatively normal in all subjects tested, suggesting that the hyperthyroxinemia resulted from a partial peripheral resistance to T4. . . .