Treatment of Pernicious Anemia by Oral Administration of Vitamin B12without Added Intrinsic Factor

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Abstract
PERNICIOUS anemia is generally considered to be a heredofamilial disease in which a lack of intrinsic factor is associated with atrophy of the gastric mucosa. As the disease develops, intrinsicfactor production decreases and then ends; vitamin B12 in physiologic amounts then cannot be transported across the intestinal mucosa, and the tissue stores of the vitamin are gradually depleted and eventually exhausted. Serum and urinary B12 levels approach zero and may be interpreted as an indication of the markedly depleted tissue stores. Nucleoprotein synthesis, especially that in the hematopoietic and nervous systems, is altered, and the clinical picture of . . .