Highly stereoselective asymmetric Michael addition reactions employing (R;E)-3,3,3-trifluoroprop-1-enyl p-tolyl sulphoxide
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 18,p. 1340-1342
- https://doi.org/10.1039/c39870001340
Abstract
(R;E)-3,3,3-Trifluoroprop-1-enyl p-tolyl sulphoxide, prepared in three steps from ethyl trifluoroacetate, showed a high degree of diastereoselectivity in Michael addition reactions with enolates; by this means, optically active trifluoromethylated organic molecules can be obtained readily in high yield as well as in high optical purity.Keywords
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