Biosynthesis of the sesquiterpenoid tricothecane antibiotics

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Abstract
A study of the incorporation of [2-3H2,2-14C]-mevalonic acid in trichodermol and tricothecin suggests that the starter methyl groups of the farnesyl pyrophosphate retain their individuality in these sesquiterpenes, that the hydroxylation at C-4 proceeds with retention of configuration, and that a ring-A epoxide such as crotocin may be a precursor of tricothecin.