Über den antimikrobisch wirkenden Stoff der Kapuzinerkresse(Tropaeolum maius)

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Abstract
T. maius contains an antimicrobial principle active against both Gram-positive and Gram-negative bacteria as well as against blastomycetes. The activity is bacteriostatic, and bacteriocidal only at high concentrations. The substance has now been isolated and characterized. Two starting materials were used: commercially prepared oil extract of the plant seeds (Tromalyt of the firm Madaus), and an ether-extract of the seeds. By means of high vacuum distillation at 40-60[degree]C it was possible to isolate benzyl mustard oil, which was characterized by means of the infra red and ultra violet spectrum. As the antimicrobial spectrum of the principle from Tropaeolum is similar to that of benzyl mustard oil, this substance was synthesized from benzylamine and carbon disulfide, and the antimicrobial properties compared. No qualitative or quantitative differences were found when the activity of the substance derived from the seeds was related to the benzyl mustard oil content. The natural and synthetic products had the same effect on the O2 uptakes of growing cultures of Bact. coli, and the same temperature-lowering activity for guinea pigs. The substance in T. maius responsible for the biological effects investigated is benzyl mustard oil.

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