HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages
Top Cited Papers
- 26 July 2002
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 5 (9) , 997-1003
- https://doi.org/10.1038/12433
Abstract
Infection of macrophage lineage cells is a feature of primate lentivirus replication, and several properties of primate lentiviruses seem to have evolved to promote the infection of macrophages. Here we demonstrate that the accessory gene product Nef induces the production of two CC-chemokines, macrophage inflammatory proteins 1α and 1β, by HIV-1-infected macrophages. Adenovirus-mediated expression of Nef in primary macrophages was sufficient for chemokine induction. Supernatants from Nef-expressing macrophages induced both the chemotaxis and activation of resting T lymphocytes, permitting productive HIV-1 infection. These results indicate a role for Nef in lymphocyte recruitment and activation at sites of virus replication.Keywords
This publication has 65 references indexed in Scilit:
- The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 IsolatesPublished by Elsevier ,1996
- CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1Science, 1996
- A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion CofactorsCell, 1996
- In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral VectorScience, 1996
- Pathway to understanding AIDSNature Structural & Molecular Biology, 1996
- Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 + T CellsScience, 1995
- Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and RecipientsScience, 1995
- Importance of the nef gene for maintenance of high virus loads and for development of AIDSCell, 1991
- Serine phosphorylation-independent downregulation of cell-surface CD4 by nefNature, 1991
- Isolation of human mononuclear cell subsets by counterflow centrifugal elutriation (CCE)Cellular Immunology, 1984