Ribavirin-Induced Pure Red-Cell Aplasia during Treatment of Chronic Hepatitis C
- 18 March 2004
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 350 (12) , 1264-1265
- https://doi.org/10.1056/nejm200403183501222
Abstract
Interferon and ribavirin in combination are the standard treatment for chronic hepatitis C. Hematologic abnormalities, including thrombocytopenia and anemia, are major side effects.1 Ribavirin is closely associated with hemolytic anemia.2 We report a case of severe anemia due to acute pure red-cell aplasia during combination therapy, which rapidly improved after the discontinuation of ribavirin.Keywords
This publication has 4 references indexed in Scilit:
- Side effects of therapy of hepatitis C and their managementHepatology, 2002
- Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus infection: Role of membrane oxidative damageHepatology, 2000
- Hematological and bone marrow effects of ribavirin in rhesus monkeysToxicology and Applied Pharmacology, 1984
- Effects of ribavirin on red blood cellsToxicology and Applied Pharmacology, 1984