Cytochrome P-450 and Drug Metabolism in Trypanosoma cruzi : Effects of Phenobarbital
- 8 October 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 194 (4261) , 195-197
- https://doi.org/10.1126/science.785602
Abstract
The epimastigotes of Trypanosoma cruzi hydroxylate drugs at substantial rates. The activity, which is of the mixed-function oxidase type, is increased by phenobarbital and is inhibited by CO, SKF 525-A, and metyrapone. The hydroxylation is paralleled by increases in free and membrane-bound ribosomes.Keywords
This publication has 10 references indexed in Scilit:
- Hemoproteins in Trypanosoma cruzi with emphasis on microsomal pigmentsInternational Journal of Biochemistry, 1976
- In vitrostudies on the differential toxicity of metronidazole in protozoa and mammalian cellsPathogens and Global Health, 1975
- Soluble cytochrome P-450 from housefly microsomes. Partial purification and characterization of two hemoprotein forms.Journal of Biological Chemistry, 1975
- Sequential Solubilization of Microsomal Mixed Function OxidasesJournal of Biological Chemistry, 1973
- Microsomal Hemoproteins in Trypanosoma cruziExperimental Biology and Medicine, 1971
- Improved Method for the Monoxenic Cultivation of Entamoeba histolytica Schaudinn, 1903 and E. histolytica-like Amebae with TrypanosomatidsJournal of Parasitology, 1968
- SPECTRAL STUDIES OF DRUG INTERACTION WITH HEPATIC MICROSOMAL CYTOCHROME1967
- Photochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase SystemsScience, 1965
- ADAPTIVELY STIMULATED O-DEMETHYLATING SYSTEM IN RAT LIVER MICROSOMES + ITS KINETIC PROPERTIES1964