Hin-mediated DNA knotting and recombining promote replicon dysfunction and mutation
Open Access
- 25 May 2007
- journal article
- Published by Springer Nature in BMC Molecular Biology
- Vol. 8 (1) , 44
- https://doi.org/10.1186/1471-2199-8-44
Abstract
The genetic code imposes a dilemma for cells. The DNA must be long enough to encode for the complexity of an organism, yet thin and flexible enough to fit within the cell. The combination of these properties greatly favors DNA collisions, which can knot and drive recombination of the DNA. Despite the well-accepted propensity of cellular DNA to collide and react with itself, it has not been established what the physiological consequences are.Keywords
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