Isoimmune Anti-IgA Causing Anaphylactoid Transfusion Reactions

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Abstract
Nonhemolytic adverse reactions to transfusion of blood and plasma have been grouped together by Mollison1 as "other unfavorable effects of transfusion." Identification of antibodies to leukocytes and platelets in some of these reactions was a consequence of development of suitable serologic methods. Application of chromic chloride as an agent for coupling purified plasma proteins to inert indicator red cells marked the beginning of yet another phase in serologic advances that enable us to detect antibodies to various plasma proteins by a very sensitive and specific passive hemagglutination method.2 This method has been rapidly exploited and applied to various protein-antiprotein systems . . .

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