The Action of Angiotensin on Renal Transport of Sodium in the Dog

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Abstract
The effect of angiotensin on renal transport of sodium was studied in 18 anesthetized dogs. The substance was administered into the left renal artery every 5 min during a 25-minute period. The right kidney was used as control. At 5 min, the angiotensin produced a decrease in glomerular filtration rate, renal plasma flow, and sodium and water excretion. At 25 min, glomerular filtration rate and renal plasma flow reached control values and sodium and water excretion rose above them. Sodium and water excretion fractions also increased significantly beyond control values. Afferent arteriolar resistance increased 5 min after administration of angiotensin and returned to control values at 25 min. Comparison of free water excretion and free water reabsorption in the two kidneys showed values close to zero in the right kidney and progressive increase in free water excretion in the left kidney. This seems to indicate that angiotensin acts at the proximal tubule.

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