6-Methylmercaptopurine: Identification as Metabolite of 6-Mercaptopurine in vivo and Its Activity in vitro
- 1 August 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 101 (4) , 766-769
- https://doi.org/10.3181/00379727-101-25088
Abstract
1. 6-methylmercaptopurine was identified as a urinary metabolite of 6-mercaptopurine in normal Sprague-Dawley rats. 2. In in vitro experiments, 6-MeMP exerted greater inhibition of both formate and glycine incorporation into the combined nucleic acid and protein fractions of Sarcoma 180 ascites tumor cells than did 6-MP.Keywords
This publication has 4 references indexed in Scilit:
- THE ANTITHYROID ACTIVITY OF 5-IODO-2-THIOURACIL1Endocrinology, 1958
- DETOXICATION OF THIOURACIL BY S-METHYLATIONJournal of Biological Chemistry, 1958
- STRUCTURE-ACTIVITY RELATIONSHIPS AMONG PURINES RELATED TO 6-MERCAPTOPURINE1958
- PURINE BIOSYNTHESIS AND INHIBITORS IN ASCITES CELL TUMORS1956