Serotonin analogs andSpisulaoocyte maturation

Abstract
Several 5-hydroxytryptamine (5-HT) agonists were used to induce maturation in Spisula oocytes and antagonists to block 5-HT-induced germinal vesicle breakdown. Among the analogs tested, only 8-hydroxy-2-(di-n-propylamino)-tetralin induced maturation of Spisula oocytes in vitro and mianserin blocked 5-HT-induced maturation. The present findings suggest that Spisula oocytes may possess 5-HT1A receptor sites.