Immunobiology of liver dendritic cells
- 1 February 2002
- journal article
- review article
- Published by Wiley in Immunology & Cell Biology
- Vol. 80 (1) , 65-73
- https://doi.org/10.1046/j.0818-9641.2001.01058.x
Abstract
Dendritic cells (DC) are rare, bone marrow‐derived antigen‐presenting cells that play a critical role in the induction and regulation of immune reactivity. In this article, we review the identification and characterization of liver DC, their ontogenic development, in vivo mobilization and population dynamics. In addition, we discuss the functions of DC isolated from liver tissue or celiac lymph, or propagated in vitro from liver‐resident haemopoietic stem/progenitor cells. Evidence concerning the role of DC in viral hepatitis, liver tumours, autoimmune liver diseases, granulomatous inflammation and the outcome of liver transplantation is also discussed.Keywords
Funding Information
- National Institute of Health (DK 49745, AI 41011, DK 57228)
- Roche Organ Transplantation Research Foundation
- Juvenile Diabetes Foundation International
This publication has 69 references indexed in Scilit:
- Chemokine and chemokine receptor expression by liver-derived dendritic cells: MIP-1α production is induced by bacterial lipopolysaccharide and interaction with allogeneic T cellsTransplant Immunology, 2000
- Absence of CD83-positive mature and activated dendritic cells at cancer nodules from patients with hepatocellular carcinoma: relevance to hepatocarcinogenesisCancer Letters, 2000
- Prognostic importance of antigen‐presenting dendritic cells during vaccine therapy in a murine hepatitis B virus carrierImmunology, 1999
- FLT3 Ligand Induces the Generation of Functionally Active Dendritic Cells in MiceCellular Immunology, 1997
- ISOLATION OF DENDRITIC CELLS IN THE RAT LIVER LYMPHTransplantation, 1995
- DELETION OF SPONTANEOUS RAT LIVER ALLOGRAFT ACCEPTANCE BY DONOR IRRADIATIONTransplantation, 1995
- The effects of genetics and age on expression of MHC class II and CD4 antigens on rat cardiac interstitial dendritic cellsCellular Immunology, 1990
- CHARACTERISTICS OF DENDRITIC CELLS IN RAT LIVERTransplantation, 1988
- Interdigitating and dendritic reticulum cells in chronic active hepatitisHistopathology, 1984
- Accessory and stimulating properties of dendritic cells and macrophages isolated from various rat tissuesThe Journal of Experimental Medicine, 1982