Effect of RO 23-6240 on sensitive and resistant intracellular mycobacteria
- 1 April 1987
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 6 (2) , 165-166
- https://doi.org/10.1007/bf02018200
Abstract
The activity of Ro 23-6240 and rifampicin against intracellular Mycobacterium fortuitum and Mycobacterium chelonei was assessed in vitro over a 48-hour period. Both agents, at an extracellular concentration of 2.0 mg/l (Ro 23-6240) and 1.0 mg/l (rifampicin), produced a significant intracellular killing of the sensitive Mycobacterium fortuitum at both 20 and 48 hours. However, neither agent was effective against the resistant Mycobacterium chelonei.It was concluded that Ro 23-6240 has a direct antimicrobial effect against sensitive intracellular mycobacteria.Keywords
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