Abstract
1. The following experiments were instituted with a view to ascertain, in what manner certain substances act on the animal system, so as to occasion death, independently of me­chanical injury. I was led to the inquiry, from the subject of it appearing to be of considerable interest and importance, and from a hope, that, in the present improved state of physiolo­gical knowledge, we might be enabled to arrive at some more satisfactory conclusions, than had been deduced from any former observations. The substances, which act as poisons when applied to the animal body are very numerous. In the experiments, which I have hitherto made, I have employed vegetable poisons only. Of these I have selected such, as are very active and certain in producing their effects, believing that, on this account, the exact nature of those effects would be more readily ascertained. The principal objects, which I have kept in view have been to determine, on which of the vital organs the poison employed exercises its primary influence, and through what medium that organ becomes affected. I have also endeavoured to ascertain by what means the fatal consequences of some poisons may be prevented. With some of the conclusions, which I have ventured to draw, so far as I know, we were not before acquainted; and others of them, though not en­tirely new, had not been previously established by satisfactory experiments.

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