Cigarette smoke enhances Th-2 driven airway inflammation and delays inhalational tolerance
Open Access
- 20 May 2008
- journal article
- Published by Springer Nature in Respiratory Research
- Vol. 9 (1) , 42
- https://doi.org/10.1186/1465-9921-9-42
Abstract
Active smoking increases asthma severity and is related to diminished treatment efficacy. Animal models in which inhalation of both allergen and mainstream cigarette smoke are combined can help us to understand the complex interaction between both agents. We have recently shown that, in allergic mice, the airway inflammation can be cleared by repeated allergen challenge, resulting in the establishment of a state of inhalational tolerance.Keywords
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