Strategy and model building in the fourth dimension: a null model for genotype × age interaction as a Gaussian stationary stochastic process

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Abstract
Background: Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype × age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. Results: We found evidence for genotype × age interaction for fasting glucose and systolic blood pressure. Conclusions: There is polygenic genotype × age interaction for fasting glucose and systolic blood pressure and quantitative trait locus × age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.